Heard of Nitazines yet? You will...

   Nitazenes are a class of extremely potent synthetic opioids that have emerged in the illicit drug supply in recent years. Though they were first developed in the 1950s as a potential alternative to morphine, they were never approved for medical use due to concerns over their toxicity and addiction potential. 

Nitazenes, also known as benzimidazole-opioids, act on the same mu-opioid receptors in the brain as heroin and fentanyl. The potency of different nitazene analogues varies, but some are hundreds of times stronger than morphine and even more potent than fentanyl. This makes them extremely dangerous and increases the risk of overdose.

Nitazenes cause typical opioid effects, including pain relief, euphoria, drowsiness, relaxation, and respiratory depression (slowed or stopped breathing). They are very unpredictable street drugs. Nitazenes are often mixed into other illicit drugs, such as heroin, fentanyl, counterfeit pills, and benzodiazepines, often without the user's knowledge. This makes the drug supply more dangerous and unpredictable.

 While naloxone (Narcan) can temporarily reverse a nitazene overdose, multiple doses may be required due to the extreme potency of these drugs.

 

The re-emergence of nitazenes has been linked to an increase in overdose deaths in the US and Europe since around 2019. Netazenes were first created in the 1950s by Swiss researchers but were never marketed for clinical use. 

They make Fentynal look like drug store penny candy.

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